Toxicological Study of Potassium Bromate. I. Absorption, Metabolism and Excretion of Potassium Bromate after Oral Administration in Rats.
نویسندگان
چکیده
منابع مشابه
Toxicological Properties of Potassium Bromate
Potassium bromate (KBrO3), used in both the food and cosmetics industry, and a drinking water disinfection byproduct, is a nephrotoxic chemical and rodent carcinogen. As KBrO3 is primarily an oxidizing compound, reactive oxygen and other species generated from bromate have been held responsible for the genotoxic, carcinogenic and toxic effects. Bromate induces primary DNA oxidative damage, muta...
متن کاملSubchronic toxicity evaluation of potassium bromate in Fischer 344 rats.
Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, thyroid, and tunica vaginalis). Weekly body weight and water consumption means w...
متن کاملAccidental Potassium Bromate Poisoning in Nine Adults
Accidental Potassium bromate poisoning is uncommon in adults, can have varied manifestations in different patients and can sometimes be deceiving. Potassium bromate white powder and oxidizing agent is used predominantly in bakeries as a maturing agent for flour and as a dough conditioner. It is also occasionally used as a neutralizer in hair kits. This paper deals with nine cases of accidental ...
متن کاملToxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
Potassium bromate (KBrO3) is an oxidizing agent that has been used as a food additive, mainly in the bread-making process. Although adverse effects are not evident in animals fed bread-based diets made from flour treated with KBrO3, the agent is carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. It has been demonstrated that KBrO3 induces renal cell tum...
متن کامل[Relationship between toxic effects of potassium bromate and endocrine glands].
Potassium bromate (KBrO(3)) is a compound belonging to Group 2B of carcinogens (a possible human carcinogen). This agent was used as a food additive in flour treatment, as a component of cold-wave hair lotions, and is still used in barley processing. Additionally, KBrO(3) is formed as an oxyhalide by-product during water ozonation. KBrO(3) induces oxidative stress and may contribute to neoplasi...
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1991
ISSN: 0013-273X
DOI: 10.1248/jhs1956.37.258